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In contrast, endochondral ossification requires hyaline cartilage differentiation from mesenchyme ahead of acquiring replaced by bone. The joint connective tissue occurs within the mesenchymal cells between the developing bones.

Although domestic Pet breeds change extensively—from little Chihuahuas to huge Excellent Danes—all of them come from the identical ancestors and share 99.9% in their DNA with the gray wolf. “Dogs ended up domesticated from a lineage of gray wolves which are extinct,” Dr. vonHoldt suggests.

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The monster I had been attacking rolled a natural twenty, landing a crucial strike that took out most of my health.

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